Prurigo nodularis is a disease where the patient experiences intense itching at discrete points and due to scratching, rubbing, and picking develops thickening of the skin in the form of nodules +/- pigmentary changes. The etiology of the intense itching is unknown. Historically this is a very difficult disease to treat, and topical steroids and antihistamines are most commonly used to control the itching.
Tamagawa-Mineoka R, Katoh N, Ueda E, Kishimoto S. Narrow-band ultraviolet B phototherapy in patients with recalcitrant nodular prurigo. J Dermatol. 2007 Oct;34(10):691-5.
This study shows that narrow-band UVB is an effective treatment for recalcitrant prurigo nodularis. It does not recommend phototherapy as a first line, but only for those patients who have failed topical steroids or antihistamines.
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