UV light has anti-inflammatory effects that can help control both psoriasis and atopic dermatitis. This treatment is used in both children and adults and is thought to be particularly effective for acute onset conditions. PUVA, UVB, and narrow-band UVB have all been used. PUVA requires the ingestion of a psoralen pill before treatment, which increases photosensitivity to UVA waves. Narrow band UVB is thought to have fewer side effects than normal UVB treatment.
There are lots of studies on the effectiveness of PUVA and UVB for psoriasis and eczema treatments. But this study discusses the mechanism of action of PUVA v, NB-UVB v cyclosporin.
Erkin G, Ugur Y, Gurer CK, Asan E, Korkusuz P, Sahin S, Kolemen F. Effect of PUVA, narrow-band UVB and cyclosporin on inflammatory cells of the psoriatic plaque.
J Cutan Pathol. 2007 Mar;34(3):213-9.
- PUVA is the only treatment that decreased Langerhans cells (CD1a+) in the epidermis
- All 3 treatments decreased T lymphocytes (CD4+ and CD8+)
- All 3 treatments reduced expression of CD86, an inflammatory stimulator
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